What is the difference between horizant and gabapentin

She reports strong, irresistible urges to move her legs when she is watching TV at night, and these worsen when she lies in bed and tries to fall asleep. She currently takes ropinirole 4mg PO 2 hours before bedtime with some improvement in her symptoms, but she would like an even greater benefit from her medication. GR would like to know if there are any additional treatments for her restless legs that may offer additional symptom relief. Gabapentin immediate release has also been used for many off-label indications, including treatment of migraine headache, fibromyalgia and neuropathic pain, and anxiety.

Gabapentin enacarbil is a prodrug of gabapentin that is absorbed throughout the entire GI tract. The ability of gabapentin enacarbil to be absorbed in the large intestine differs from traditional gabapentin and contributes to its long-acting nature. Gabapentin enacarbil undergoes extensive 1 st -pass hydrolysis by non-specific carboxylesterases to form gabapentin, carbon dioxide, acetaldehyde, and isobutyric acid.

Gabapentin enacarbil is supplied in mg extended release tablets. The recommended dose is mg daily at 5pm with food. Gabapentin enacarbil tablets should be swallowed whole and should not be cut, crushed, or chewed.

A dose of 1, mg once daily provided no additional benefit compared with the mg dose, and caused an increase in adverse reactions. Gabapentin enacarbil can be abruptly discontinued in patients taking the mg once daily dose. If this dose is exceeded, the dose should be tapered to mg daily for one week prior to discontinuation. The package labeling states that gabapentin enacarbil is not interchangeable with any other forms of gabapentin due to differing pharmacokinetic profiles.

Neither gabapentin enacarbil nor gabapentin are substrates, inhibitors, or inducers of the major cytochrome P enzymes. Gabapentin enacarbil is neither a substrate nor an inhibitor of P-glycoprotein in vitro. Pharmacokinetic drug-drug interaction studies were conducted and no significant pharmacokinetic interactions were observed.

Apparent oral clearance was decreased in moderate and severe renally-impaired patients. Dosage reduction in patients with renal dysfunction is necessary. For patients on hemodialysis, treatment with gabapentin enacarbil is not recommended. Like all anti-epileptic drugs, gabapentin enacarbil carries the same FDA risk warning for increasing suicidal thoughts or behavior in patients taking these drugs for any indication. Gabapentin enacarbil is classified as Pregnancy Category C; however, there are no adequate and well-controlled studies with gabapentin enacarbil in pregnant women.

The effectiveness of gabapentin enacarbil in the treatment of moderate-to-severe primary RLS was demonstrated in two week randomized, placebo-controlled clinical studies in adults diagnosed with RLS using the International Restless Legs Syndrome Study Group diagnostic criteria. Subjects receiving treatment for RLS at screening will be required to discontinue and wash out for a minimum of 5 half-lives.

Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.

More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Restless Leg Syndrome. Drug: Gabapentin immediate release Drug: Gabapentin enacarbil extended release. Phase 4. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Actual Primary Completion Date :. Active Comparator: gabapentin immediate release Gabapentin IR is the immediate release form of the medication.

Drug: Gabapentin immediate release up to mg per day Other Name: Neurontin. Active Comparator: gabapentin enacarbil extended release Horizant is the extended release form of gabapentin enacarbil. Drug: Gabapentin enacarbil extended release up to mg per day Other Name: Horizant. RLS and Gabapentin or Horizant. We make no warranty regarding any goods or services purchased or obtained through this Web site or any transactions entered into through this Web site.

You assume the entire risk as to the results and performance of this Web site and any goods or services purchased therefrom. You agree to indemnify, defend and hold harmless Arbor Pharmaceuticals, LLC, its subsidiaries, affiliates, directors, officers, employees, agents, consultants, business partners and assigns of same from and against any and all loss, costs, expenses including reasonable attorneys' fees and expenses , claims, damages and liabilities related to, or associated with, your use of this Web site and any hyperlinked Web site or based on any reliance upon the information contained therein and any violation of these Terms of Use by you.

Applicable law may not allow the exclusion or limitation of incidental or consequential damages, so the above limitation or exclusion may not apply to you. You agree not to do any of the following while visiting or using this Web site or any services provided by or through this Web site:. Arbor Pharmaceuticals, LLC may, at its sole discretion, take any action we deem necessary, including, but not limited to, termination of access to this Web site, if we believe a user's conduct or content fails to conform to the terms and conditions provided in these Terms of Use or may create liability for Arbor Pharmaceuticals, our affiliates, partners, suppliers or other users.

Arbor Pharmaceuticals will not be liable to you or any third party as a result of such termination and modification. The terms and conditions provided in the Terms of Use will survive any such termination and modification. When you are leaving our Web site, we use the following symbol to indicate that you are leaving our Web site. Access to any other Web site is at your own risk, and we are not responsible for the accuracy or reliability of any information, data, opinions, advice or statements accessible from these Web sites, and we do not make any representations or warranties about them.

We provide these hyperlinks merely as a convenience, and the hyperlinks are not an endorsement of any product, service, individual, or entity. We reserve our right to any remedy available at law or equity in the event of your breach of these Terms of Use. All matters arising from, or related to, these Terms of Use and your access to, or use of, the Web site shall be governed by U. You agree that you will bring any legal action or proceeding arising from, or relating to, your access to, or use of, the Web site exclusively in a state court in Santa Clara County, California, or in the U.

You agree to submit to the jurisdiction of, and agree that venue is proper in, such courts in any such legal action or proceeding. Any rights not expressly granted in our Web site are reserved to us. If any provision of these Terms of Use is held to be invalid or unenforceable, such provision shall be struck and the remaining provisions shall be enforced.

Any use of "Arbor Pharmaceuticals" except as permitted herein is prohibited and may be in violation of trademark law and other laws. All trademarks, logos, trade names, trade dress, service marks and products of Arbor Pharmaceuticals "Marks" displayed on our Web site are the property of Arbor Pharmaceuticals or third parties, are protected in the United States and internationally and may not be used for advertising or publicity purposes, or to indicate any affiliation with, or endorsement by, Arbor Pharmaceuticals.

These Marks may not be used in whole or in part without the prior written permission of such owners. Access to, and use of, this Web site is subject to the above Terms of Use. This Web site was developed and is maintained by Arbor Pharmaceuticals. This information is intended only for residents of the United States.

Arbor Pharmaceuticals is aware of our visitors' concern for privacy when using this Web site. We want to give our Web site visitors the opportunity to know what information we collect about them and how they can limit the use of individually identifiable information beyond the purposes for which they first provided it. At all times, however, we reserve the right to disclose information where required by law or to comply with valid legal processes such as a search warrant, subpoena, or court order to protect the company's rights or property, including, without limitation, the right to transfer the data in the event of a transfer of control of Arbor Pharmaceuticals or the sale of substantially all our assets, or during emergencies when safety is at risk.

Please be sure to read this entire Internet Privacy Statement before using or submitting information to this Web site. By using this Web site, you agree with the terms of this Internet Privacy Statement. Whenever you submit information via this Web site, you consent to the collection, use, and disclosure of that information in accordance with this Internet Privacy Statement.

Your use of this Web site is also subject to the Terms of Use for this Web site, which is incorporated herein by reference. If you request company information through Horizant. We collect personally identifiable information from Web site visitors only when it is voluntarily provided. The personal data you provide is considered private and confidential. It will be collected by a third-party vendor that acts as a hosting service for our Web site.

This information may also be retained by an outside vendor for storage purposes. We will not sell, rent or exchange your personally identifiable information with unaffiliated entities without your express consent to such transfer. We may also collect information obtained from you on registration forms used to process your requests for services and information, such as contact information name, address, e-mail address , password, username or code, age, date of birth, gender, ethnicity and medical condition.

This registration information may also be gathered if you register for certain services via fax or mail. We may use this information to send you a welcoming e-mail to verify your username and password, Web site updates, special offers, notices regarding relevant medical conditions and treatment, or other information responsive to the data that you provide to us. Additionally, we may refer to your personally identifiable information to better understand your needs, to improve our Web site and our services, or to send updates or notices about our company and the products we offer that we think may be of interest to you.

We may also combine the personally identifiable information you provide with other generally or publicly available information to help us identify visitors' preferences or interests. We may use the information to improve the content of our Web site or our products and services.

Again, we do not sell, rent, or otherwise share with unaffiliated entities any personally identifiable information we collect unless you are first notified and expressly consent to such transfer. Our Web server captures the internet protocol IP addresses of each connection to our Web site and the specific Web pages visited during that connection.

An IP address is a number assigned to your computer by your internet service provider so you can access the Internet. It is generally considered to be non-personally identifiable information because in most cases it changes each time you connect to the Internet.

IP addresses may be used to diagnose problems with our server, report aggregate information, determine the fastest route for your computer to use in connecting to the Web site, and administer and improve the Web site. Although the IP address and related information collected is stored in the server log files, no individual is authorized to access those files for any purpose other than system maintenance.

We may also use this information to help improve our Web site and our services by better understanding our audience. We may also collect non-personally identifiable information in aggregate form to track data such as the total number of visitors to each page of our Web site, and the domain names of our visitors' Internet service providers. We may use this information, which remains in aggregate form, to understand how our visitors use our Web sites so that we may make them better.

Arbor Pharmaceuticals does not knowingly collect any personally identifiable information from children under 13 years old through this Web site. However, if the parent or the guardian of a child under 13 believes that the child has provided us with personally identifiable information, the parent or guardian of that child should contact us to request that this information is deleted from our files.

Anyone under 18 years old should seek a parent's or guardian's permission prior to using or disclosing any personal information on this Web site. We want to be sure that we keep only the most accurate and up-to-date information about you in our records. Therefore, whenever you believe that your contact information needs to be updated, you can contact us to correct or update your contact information.

You may choose at any time to remove your name, telephone number and postal and e-mail addresses from the list we use to send notices or updates and elect not to receive correspondence from us by contacting us. We take reasonable steps to protect your personally identifiable information as you transmit your information from your computer to our Web site and to protect your information from loss, misuse and unauthorized access, disclosure, alteration or destruction.

All information transmitted to this Web site is secure to the extent possible using existing technology. In particular, e-mail sent to or from this Web site may not be secure, and you should therefore take special care in deciding what information you send to us via e-mail. Moreover, where you use passwords, ID numbers, or other special access features on this Web site, it is your responsibility to safeguard them.